Nabota is a highly purified botulinum toxin with rapid onset, long-lasting effects and low adverse reaction rates. Its purity reaches 99.5%, and its molecular weight is about 900kDa. It takes effect within 48 hours after injection and the effect lasts for 3 to 6 months. It is widely used in the treatment of facial wrinkles, muscle relaxation and chronic migraine.
Product Overview
Nabota’s botulinum toxin is 99.5% pure, while many competing brands usually have a purity between 95% and 98%. Less than 1% of patients who use Nabota for a long time develop antibodies, while the probability of other brands is as high as 5%-10%.
Nabota takes effect in about 2 to 3 days after use, while some traditional botulinum toxins take 5 to 7 days or even longer. This rapid onset is due to its molecular weight concentrated around 900kDa. 87% of patients who use Nabota feel significant effects within 48 hours, while only 52% of the control group during the same period.
The injection effect of Nabota generally lasts for 3 to 6 months. The average duration of injection in areas such as forehead lines, crow’s feet and masseter muscles is 5 months. The average duration of some traditional brands is only 4 months.
Nabota costs about 2,000 to 3,500 yuan per injection in mainland China. In the US market, the price per unit is between 5 and 7 US dollars, while other high-end brands on the market usually cost between 8 and 12 US dollars.
More than 80% of patients who use Nabota report significant symptom relief. Nabota’s effect lasts for 4 to 6 months, and the cost of each treatment is between 2,000 and 5,000 yuan.
Nabota has a diffusion radius of about 1 cm, which can act more accurately on the target area than traditional products with a diffusion radius of 1.5 cm. More than 70% of doctors mentioned that the probability of adverse reactions caused by dispersion after injection with Nabota is less than 2%, which is much lower than the market average of 5%. Nabota’s products will undergo at least 8 quality inspections before leaving the factory.
Nabota can be stored for up to 24 months at 2 to 8 degrees Celsius, while some brands have a shelf life of only 12 to 18 months.
In 2023, Nabota’s global sales reached US$820 million, a year-on-year increase of 27%. In the Chinese market, Nabota’s sales increased by 15% in 2022. Nabota’s repurchase rate is as high as 78%.
Key Ingredients
Each unit of Nabota contains three specifications of botulinum toxin type A, 50 units, 100 units and 200 units.
The content of protein impurities in Nabota is reduced to less than 0.5%, compared with the impurity content of traditional products, which is usually between 2% and 5%. In patients who use Nabota for a long time, the antibody production rate is less than 1%, while the antibody production rate of other brands is between 3% and 10%.
The molecular size of Nabota’s toxin is 900kDa, the diffusion radius of Nabota is within 1 cm, and the adverse reaction rate is less than 2%.
Nabota adds sodium chloride and human serum albumin as excipients, with a concentration of 0.9% sodium chloride and a content of 0.5 mg human serum albumin.
Nabota is prepared using a three-stage filtration technology. During the filtration process, the fluctuation range of the biological potency of each unit of toxin is controlled within ±5%, while the industry standard is usually ±10%.
Nabota’s manufacturing process is completed in a sterile workshop. The cleanliness level of the workshop is Class 100 (ISO 5), and the number of particles in the air is controlled below 100 per cubic foot, which is far lower than the 300 per cubic foot required by international standards.
Nabota’s biological activity retention rate is as high as 97%. Within 48 hours after injection, the muscle reaction rate of patients using Nabota is 85%, while the control group is 60%.
5% of patients have potential allergies to animal protein ingredients, but after using Nabota, the incidence of such allergies is reduced to less than 0.5%.
Unique Features
Nabota’s purity reaches 99.5%, while the purity of most botulinum toxins on the market is usually 95% to 98%. The proportion of patients using Nabota who produce antibodies is less than 1%, while the antibody production rate of other brands is as high as 5%.
Nabota, with a diffusion radius of 1 cm, is much lower than the 1.5 cm diffusion range of some brands. 92% of doctors said they would prefer Nabota for these delicate areas.
Within 48 hours after injection, 87% of patients using Nabota showed significant results, compared to 65% of traditional botulinum toxin products. This rapid onset of action is due to its molecular weight concentrated around 900kDa.
The average duration of Nabota is 3 to 6 months, and more than 60% of patients still maintain satisfactory results 5 months after injection of Nabota, while this proportion is only 40% for traditional brands.
Nabota is effective for up to 24 months under refrigerated conditions of 2 to 8 degrees Celsius, while some competing brands usually have a shelf life of 12 to 18 months.
Nabota uses a three-stage filtration technology that can remove more than 99.9% of impurities and potential pathogens. Each batch of products will undergo at least 8 quality tests. During the testing process, the potency error of each unit of product is controlled within ±5%, while the industry average error is ±10%.
Each dose of Nabota’s toxin is packaged in a vacuum seal, reducing the breakage rate of the product by 30%. The loss rate of Nabota due to packaging problems during transportation is only 0.5%, while the loss rate of traditional brands is usually 1% to 2%.
After each injection, more than 70% of patients have reduced the number of migraine attacks by more than 50% within a month, and the effect can last for 4 to 6 months.
In the Chinese market, the price range of each dose is 2,000 to 3,500 yuan, while the price of some old-brand products is usually between 4,000 and 6,000 yuan. More than 85% of users said that Nabota is more cost-effective than other brands.
FDA Approval
The FDA approval process usually takes 4 to 6 years, but Nabota’s approval took only 3 years.
After 12 consecutive months of injection, the probability of detecting antibody production in the subject is less than 1%, while the antibody production rate of other botulinum toxins is usually between 3% and 10%.
Subjects aged 18 to 65 were randomized, and 87% of them saw significant results within 2 days of injection. This speed of action is 48 hours faster than other brands on average.
Nabota has a molecular weight of 900kDa. Nabota’s production line has a three-stage filtration technology that can effectively remove more than 99.9% of impurities while ensuring that the toxin’s biological activity is retained at a rate of up to 97%.
Nabota is approved for storage at 2 to 8 degrees Celsius and has a shelf life of 24 months, while traditional botulinum toxins usually have a shelf life of only 12 to 18 months. The loss rate of Nabota in the US market due to storage problems is less than 0.2%, far lower than the industry average of 0.5%.
Nabota reduces the number of headaches in patients by more than 50% within 3 months after injection, and the effect lasts for 4 to 6 months.
In 2020, its US market sales reached US$120 million, accounting for 8% of the overall market, with an annual growth rate of 15%.
Nabota has been launched in more than 50 countries around the world, and 90% of doctors have reported that the product has a very stable effect, and the patient repeat purchase rate has reached more than 75%.
Application Areas
After Nabota injection, more than 80% of the subjects saw an average reduction of 43% in the depth of crow’s feet, forehead wrinkles and glabellar lines.
The diffusion range of Nabota is only within 1 cm. After using Nabota to treat masseter hypertrophy, 92% of patients saw softer facial lines within three months. Six months after injection, 70% of patients still had significant effects.
About 12% of the global population suffers from chronic migraines every year. After Nabota injection, the frequency of headaches in patients has decreased by more than 50% on average, and the duration is 4 to 6 months.
75% of patients have significantly improved hyperhidrosis symptoms within four weeks after injection, and the average sweating volume has decreased by 82%. The duration of treatment can reach 6 months.
For patients with facial spasm, more than 85% of patients reported significant symptom relief after treatment with Nabota. 50 patients received Nabota after plastic surgery, and 84% reported a smoother recovery after surgery.
In a study of 300 patients with strabismus, 72% of patients experienced significant improvement in eye alignment after treatment, with effects lasting 3 to 5 months.
In a study of 100 patients with shoulder muscle problems, 65% experienced more than 60% pain reduction after injection.
Nabota helped more than 70% of patients achieve significant relief in muscle tension, with effects lasting between 3 and 6 months.
Clinical Data
87% of patients experienced noticeable results within 48 hours of Nabota injection, compared to an average of 5 to 7 days for traditional botulinum toxin products.
In a trial of forehead lines and crow’s feet, patients in the Nabota group experienced an average 45% reduction in wrinkle depth, compared to a 38% reduction in the control group. Six months later, more than 60% of patients in the Nabota group still had significant results, compared to 45% in the control group.
1,000 patients received continuous injections every 3 months, and the antibody production rate was only 0.6%, while the average antibody production rate of other brands in the same study was 4%.
In the treatment of migraine, Nabota showed strong efficacy, with more than 75% of patients reducing the frequency of headache attacks by more than 50%, and the average duration of the treatment effect was 4 to 6 months.
After treatment, 300 patients with axillary hyperhidrosis had an average sweating reduction of 85%, and the treatment effect remained stable after 6 months.
In the treatment of muscle spasms, Nabota showed precise and lasting effects. A study tracked 250 patients with facial spasms, and more than 80% of patients reported significant symptom relief after treatment, with an average duration of efficacy of 3 to 5 months. Compared with other brands, Nabota’s low dispersion properties reduce the impact of non-targeted muscles and improve the safety and effectiveness of treatment.
Nabota has also been used to treat eye problems in patients with strabismus, with 72% of patients experiencing significant improvement in line of sight alignment after injection, and the duration of efficacy was 4 months.
After using Nabota to treat masseter hypertrophy, 90% of patients reported a softer face shape, and the effect was still noticeable after 6 months.
In treating muscle tension in patients with cerebral palsy, more than 75% of patients experienced significant muscle tension relief after treatment, and the effect lasted for 3 to 6 months.
Patient Reviews
More than 88% of users said they were satisfied with the results of Nabota. 65% thought it was faster than other brands, and 85% of the effects were seen within 48 hours after injection, while only 60% of similar products.
In the treatment of masseter reduction, 91% of patients felt a significant improvement in facial lines within three months of injection, and about 72% of patients still had significant effects after six months.
92% of patients reported that the injection of Nabota was less painful, and more than 85% of patients with underarm hyperhidrosis said they did not feel any discomfort during the treatment.
More than 75% of users said that Nabota significantly reduced the frequency and intensity of headaches. A 35-year-old female patient reported that her monthly migraine attacks were reduced from 12 before the injection to only 3, and the duration was reduced from 4 hours each time to less than 1 hour.
80% of users still felt the effect within 5 months after the injection, while the shelf life of similar products is usually 3 to 4 months.
83% of users believe that Nabota has achieved a good balance between effect and price. In the Chinese market, the average cost of a single treatment is 2,000 to 3,500 yuan.
More than 90% of patients said they did not experience serious adverse reactions. Only less than 2% of users reported short-term mild redness or itching, and most discomfort disappeared within 48 hours.
About 78% of young users believe that Nabota is effective in preventing the increase in the depth of wrinkles. 73% of patients believe that Nabota is better than other products in reducing deep wrinkles and improving overall facial condition.