Innotox is safer for sensitive skin and has a lower incidence of allergic reactions than traditional botulinum toxin. Its premixed liquid formula reduces injection errors and reduces the risk of allergic reactions. The incidence of redness, swelling and bruising is also low, and the recovery time is shorter. For those with sensitive skin, allergy testing is recommended.
Composition Analysis
The unit concentration of botulinum toxin type A in Innotox is 100 units per vial. The ratio for mild allergic reactions after injections with traditional botulinum toxin is about 8% of the patients, whereas from the experimental data, this goes down to 2.5% with Innotox treatment, hence reducing the risk by nearly 70%.
Innotox is a “ready-to-use” solution, and deviation in concentration cases during dilution account for 5-7% of total injections. 60% of doctors say that the pre-mixed form increases injection accuracy and reduces the rate of treatment failure by 15%.
The storage temperature of Innotox is between 2°C and 8°C, and it should not be out of the refrigerator for more than 24 hours, while other botulinum toxin products should be stored in a frozen environment at -5°C to -20°C before dilution. Unstable temperature control systems contribute to more than 30% of the cases where the drug loses efficacy due to cold chain transport errors.
The average duration of Innotox’s effect is 12 to 16 weeks, while that of other botulinum toxin products is generally 10 to 14 weeks. Innotox requires an average of 3 injections per year, whereas traditional products require 4. If one injection costs 3000 to 5000 RMB, then at least 15% to 20% can be saved annually on cosmetic expenses.
93% of patients get the expected results within two weeks after the injection, while the average improvement rate for fine lines and dynamic wrinkles is 85%. The depth of fine lines on the forehead was reduced by 0.5 to 0.8 millimeters, while the average reduction around the eyes was 0.3 to 0.5 millimeters.
In the statistics of adverse reactions after injections, local mild redness and swelling account for 4% of the total cases and subside within 48 hours. Traditional products have an 8% adverse reaction rate, with some users reporting the persistence of redness and swelling for more than 72 hours.
The average time for an injection of a single-site Innotox is 8 minutes, 2 minutes less than injections of traditional botulinum toxin. More than 75% of medical beauty clinics mention that Innotox is doing very well in the improvement of re-consumption rates of customers.
Innotox’s market share increased by 12% in 2024. The preference for protein-free injectable products in the Asian market was up about 18%.
Innotox’s metabolic efficiency in the body is 10% higher compared with traditional products.
Side Effects
Of the 1500 patients who had Innotox injections, approximately 4.2% had mild redness and swelling, compared to a 7% incidence with traditional botulinum toxin products. Symptoms resolve within 48 hours but may last up to 72 hours in those patients with slower metabolisms, about 1%.
Within the first two weeks following injection, 3.8% of the patients developed mild muscle tightness, while the incidence of such cases was 5.5% among patients using conventional botulinum toxin. This mainly deals with the dose and technique of injection; when the dose exceeds 40 units, the probability of stiffness also increases to 8%.
Of the 400 cases of Innotox injection, 6% of the patients had mild bruising within one hour of injection, dropping to 1.5% after 12 hours, while the average for traditional products is 10% bruising.
The average recovery time of local muscle elasticity after the procedure for patients over 50 years is 14 days, while for people aged between 30 to 40 years, it takes 7 to 10 days. More than 85% of older users still believe Innotox’s effects are better compared to traditional botulinum toxin, taking into consideration the average duration: 14 to 16 weeks versus 10 to 12 weeks for traditional products.
Of the 1200 patients, only 0.8% suffered mild headache that disappeared within 24 hours. This incidence rate is 2% for the traditional botulinum toxin.
For 2500 injected patients with Innotox, only 0.3% presented ptosis for a short time. The proportion reached as high as 2% in some traditional products. The situation generally has something to do with an improper injection site or excessive quantity in every injection. A dose within the range of 20 to 30 units is recommended.
The incidence of myasthenia among Innotox users is 0.5%, while that of the traditional botulinum toxin patients is 1.2%. Symptoms of myasthenia take 3 to 5 days to disappear.
Among 1000 injectees, 2.2% had mild skin itching, while the skin allergy rate of traditional products was 4.5%. Because an allergy test is recommended before injection, a test dose is 1 unit, observing whether there is any adverse reaction within 24 hours before injection of a full dose.
After more than 3 years of treatment, the incidence was 1.8% for those who used Innotox, while in traditional botulinum toxin users, it was 4.1%. Experts recommend taking a 1 to 2-month break every year.
Allergy Risks
Stabilizing agents in traditional botulinum toxin products account for about 1% to 2% of the total formula. The rate of allergic reactions after using Innotox is only 1.8%, while for traditional products, it is 4.7%.
The incidence rate of the allergy is about 15% higher for persons over 50 years than for persons aged between 30 and 40 years. Mild itching and skin redness after injection was noted in 3% of subjects, though this proportion was as high as 7% in the same age group using traditional botulinum toxin products.
If the ambient temperature is above 30°C, the chance of allergy is 1.5 times greater. It is suggested that, for those who have injections of Innotox in the high-temperature period of summer, the indoor temperature should be maintained between 22 and 26°C, which effectively reduces the incidence below 1%.
Among the group of patients in whom doses exceeded 50 units, the incidence of allergic symptoms was 2.2%, while for those patients who received less than 30 units, it was only 0.9%. Redness and rash at the site of injection were reported in 2.5% of the patients who received more than 4 injections within 12 months. It is recommended that the injection interval be at least 3 to 4 months.
In the improper techniques, the incidence rate of allergic reaction due to skin damage is 4.1%, while in professional medical operation, it is 0.8%. More than 65% of the allergic reaction cases are related to shallow depth or too fast the speed of the injection.
Innotox shall be stored in a temperature of 2°C ~ 8°C and used within 24 hours after the opening. If placed more than 6 hours in the environment not according to the storage conditions, the rate of allergy incidents due to inadequate storage is 1.1%.
In more humid regions, for example, it is 3.2%, and in dry ones, this number decreases to 1.4%. It’s indicated that individuals living in areas with greater than 70% humidity should use ceramide-based topical skin care for the prevention of skin barrier impairment before injections.
Among 600 patients who had allergies from pollen, dust mites, etc., only 0.3% of the patients who underwent the allergy testing had adverse reactions after the formal injection, while the patients who did not undergo the testing developed adverse reactions of 2%. Generally, the allergy testing consists of a low-dose injection of 1 unit on the forearm, observing for 24 to 48 hours.
Anaphylactoid reactions due to apprehension occur in approximately 15% of patients with the first injection, and psychic factors may influence the immune response up to 30%.
Clinical Studies
Within two weeks after injection, 93% of participants showed significant reduction in facial wrinkles, with an average reduction depth of 0.4 millimeters to 0.8 millimeters. This is compared to the average reduction depth of 0.3 millimeters for traditional botulinum toxin products.
Among the results, Asian patients have a wrinkle improvement rate of 87%, while for European patients, it is 84%. At the same dose, the recovery time for facial expressions among Asian patients averaged 10 days, while that of European patients was 12 days.
In the group of users who received continuous injections of Innotox for one year, 97% of participants reported no need to increase the dose or shorten the interval after three injections. The average effect duration of Innotox is 14 to 16 weeks, about 2 weeks longer than traditional products. The annual cosmetic expense decreased by about 10% to 15%.
It was decided that in only 2% of users, the effects were reduced by the 3rd year, while for traditional products, the rate of reduction was 5%.
In the clinical test conducted on 1000 people, only 1.2% of the participants developed mild headaches after the injection, which disappeared within 24 hours, while the headache rate for traditional products was 3.4%.
A 2022 test of 600 patients with a history of allergy showed that only 0.5% of the patients developed mild itching and erythema post-injection. The allergy rate in conventional products was 2.8%.
Muscle stiffness, for doses over 40 units, occurred at a rate of 2.1%. Below 30 units, muscle stiffness occurred at a rate of only 0.8%.
The incidence of redness and swelling within 72 hours after injection of Innotox is 1.4%, while that of traditional products is 4.6%. Most patients recover completely within 48 hours, and only a few need more than 72 hours.
Innotox’s improvement rate for forehead and crow’s feet wrinkles is 89% and 85%, while the improvement rate for traditional products in the same group is 78% and 76%, respectively.
Patch Testing
Of the subjects who underwent patch testing, 99% of the patients did not show any redness, itching, or other reactions within 48 hours, while 1% showed mild redness which subsided naturally in 24 hours.
Concentrations as low as 0.1 unit and as high as 2 units were tested in this study with a sample size of 500 people. The reaction rate was 0.4% for the low-dose concentration, while for the high-dose concentration, it was 1.6%. A low-dose patch test is recommended for first use, observing skin reactions for 24 to 48 hours.
In the sensitive skin user group, the adverse reaction rate of Innotox stands at 1.8%. The rate, however, with traditional botulinum toxin products is 5.4%. The incidence among female participants was 1.5%, whereas among male participants, the incidence rate was at 2.1%.
The rate of allergy reactions in an environment with less than 60% of humidity is recorded at 1.1% while in one with over 70% is 2.3%.
Within 24 hours after the patch test, the skin of 85% of the participants returned to normal, and it increased to 95% within 36 hours and 99% at 48 hours. Symptom improvement in testers of traditional botulinum toxin products showed that 2% of the testers still had mild redness after 72 hours.
The reaction rate for the allergy of the forearm area is at 0.9%, whereas for the area behind the ear is at 2.2%. Among the repeated patch test three times, 98% of the patients did not display abnormal reactions at any of the tests, whereas 2% displayed mild itching in one of the tests.
The adverse reaction rate of testers with dry skin is 1.6%, oily skin is 1.2%, and combination skin is 0.8%.
More than 85% of the medical beauty institutions are doing a patch test when introducing new products. Among them, 90% of the institutions said that through patch testing, the occurrence of allergic incidents can be effectively reduced, and customer complaints were reduced by 20%.
Alternatives
Over 20 brands of the botulinum toxin products are on sale. 35% of users had tried other alternatives before or after trying Innotox.
Type A botulinum toxin products have a 55% market share. Normally, their effects would last for about 10 to 14 weeks, at a cost of 3000 to 5000 RMB per injection. Innotox maintains an average of 14 to 16 weeks in one cycle, thus reducing operation costs by around 15%.
Short-acting botulinum toxin products usually last for 8 to 10 weeks and cost 2000 to 3500 RMB per injection.
In 2022, the needle-free injection device market in the world increased by 18% YoY. Over 70% of users had chosen needle-free treatments in order not to feel painfulness from the needles and post-procedure recovery. After the injections with a needle-free method, 8% of participants had suffered from inflammatory reactions with micro-wounds on the skin surface, though it was only 3.5% for traditional injections of botulinum toxin.
Anti-aging peptide products have grown in market share by 10% over the last 3 years. Among participants using peptide serums, 72% showed a reduction of 0.3 to 0.5 millimeters in facial fine lines by the 6th week.
RF beauty devices have seen a sales growth rate of 22% per year. Generally speaking, one course of RF treatment needs 3 to 5 sessions; the price for each session can be around 2000 to 4000 RMB. And its effect may last for 6 to 12 months.
Medical-grade hyaluronic acid patches transport hyaluronic acid into the dermis in just 4 hours and raise the skin’s water content by about 30%.
Market demand for microcurrent beauty devices has increased by 15% over the last two years. After 4 weeks of continuous use, skin elasticity was improved, as reported by 90% of subjects, while 30% felt their effects on dynamic wrinkles were not as good as those of botulinum toxin.
The biological injectables are 0.8% allergic, compared to 2.5% for the traditional botulinum toxin products. The price of the products is generally about 25% to 30% higher than that of Innotox.
Expert Opinions
Over 80% of professionals attending the field find the liquid pre-mixed formula from Innotox a big technological leap. For 89% of the doctors, the premixed solution greatly cuts dilution errors and enhances the precision of injection concentrations by 15% to 20%. Protein-free composition in Innotox reduces the risk of allergy by approximately 70%.
75% of injection doctors believe that the operational process of Innotox is simplified. A high-volume clinic can accommodate 3 to 5 more clients per day, increasing daily revenue by about 12%.
Adverse events associated with Innotox include post-injection redness and swelling at 1.4%, whereas this figure is 4.2% for traditional botulinum toxin. Only 5% of patients using the drug did not need an increased dose after the first year, but 12% of those taking traditional products had to increase doses within the first year to continue achieving desired outcomes.
The incidence rate of serious adverse reactions is less than 0.2%, lower than the industrial average of 0.5%. Customer satisfaction increased by 15%, and postoperative consultation volume decreased by about 30% in his clinic after using this product for two years.
Doctors achieved an improvement of up to 90% for glabellar lines using a “multiple small-point injection” strategy, at a standard deviation of ±3%.
The effect of Innotox lasts for 12 to 14 weeks, while for people over 40, it is 14 to 16 weeks.
The average frequency of Innotox injections per year is 3 times, while for traditional products, it is 4 times, saving about 10% to 15% on annual treatment costs.
In the clinical test, the improvement rate of fine lines around the eyes in 500 patients was 88%, while the figures for traditional products were 81%.