Hyaron is a hyaluronic acid treatment for the under-eye area, providing effective hydration, reducing fine lines and puffiness. It is cost-effective, with a low incidence of side effects and results lasting 3-6 months.
Hyaron Overview
It estimates that the hyaluronic acid-related product market has reached a size of $14.2 billion, with an annual growth rate of 13.7%. Hyaron has about an 8% share of the market in the Asian region. To be more specific, under-eye area applications account for about 20% of the total hyaluronic acid injection treatments by Hyaron.
Hyaron has a molecular weight from 100,000 to 300,000 Daltons. Clinical use controls the depth of injection between 1.5 and 3 millimeters and an injection dose of 0.5 to 1 milliliter. Cross-linked hyaluronic acid, such as Juvederm, is of a molecular weight more than 1,000,000 Daltons.
The price for one Hyaron syringe is generally between 300 to 500 RMB. The number of syringes needed in the under-eye area is generally 1 to 2, so the cost is between 800 to 1,500 RMB. For a detailed cost comparison, other high-end injection products cost between 2,000 to 4,000 RMB per treatment. Of the consumers who have chosen Hyaron treatment, 86% said the cost was acceptable.
Hyaron treatment increased the moisture content of the skin by 35% and reduced the depth of fine lines by about 18% in 50 participants. The treatment effects usually last for 3 to 6 months.
Side effects from the use of Hyaron under the eyes occur in about 6% of cases and resolve themselves in 1 to 2 weeks. Serious complications, such as vascular embolism, occur in 0.05% of cases.
83% of the respondents believed the under-eye tear troughs and fine lines improved, and 17% believed that the effects were not obvious or temporary.
Safety Data
The complication rate for hyaluronic acid products is less than 0.1%, and for the non-cross-linked hyaluronic acid products, the complication rate of Hyaron is only 0.06%. Fewer than 50 out of 10,000 patients treated with injections of Hyaron reported mild adverse reactions.
Special adverse reaction probability is around 6%, usually by itself within 7 to 14 days to alleviate. Research indicates that symptoms improved after cold compress application in as many as 82% of subjects. The complications with more serious cases are 0.02% only. 99.5% of patients did not experience allergic reactions after injection, only 15 persons had mild allergic symptoms such as local itching.
Hyaron products need to be stored in places at temperatures within +2+25°C with an overall humidity that does not exceed 60%. Under the conditions mentioned above, product stability is available beyond 12 months. For standards of storage which are above these specifications, the breakdown tendency of this product is speedy; therefore, reducing its effective proportion by above 40% with regard to biological functioning. For more details on treatment options, visit our laser or Innotox comparison guide.
About the depth of injection in the peri-orbital region, as a general advice, Hyaron should be injected into the superficial dermis at a depth of 1.5 to 3 millimeters. 96% of the patients did not show significant discomfort or side effects, while in depths extending beyond 3 millimeters, the incidence of discomfort went up to 12%.
Hyaron has a molecular weight range between 100,000 to 300,000 Daltons and becomes completely absorbed during the first hours, after about 4-6 hours. Hyaron is metabolized in 3 to 6 months compared to cross-linked hyaluronic acid, which metabolic cycle is greater than 12 months.
Generally, for the under-eye area, one can inject Hyaron once every 3 to 6 months. Among all the patients with injection intervals less than 2 months, the incidence of mild discomfort rises to 15%, while for more than 3 months it falls to 6%.
Patient satisfaction stands at 88% with injection doses of between 0.5 to 1 milliliter, while it is reduced to 72% with doses of more than 1.5 milliliters.
Hydration Benefits
Hyaron significantly increased the average skin moisture content by 42% compared with pretreatment values. The maximum effect occurred within 24 h after the injection and remained unaltered over the succeeding 7 d. Skin hydration was enhanced by 35% relative to the pretreatment level, nearly three times higher compared to the non-treated group.
Every gram of the hyaluronic acid, Hyaron can absorb and retain approximately 1,000 milliliters of moisture. For more insights on filler options, explore this Juvederm price comparison. Two weeks later, skin moisture content in patients who got injections of Hyaron increased 18 percentage points more than that of patients using only moisturizing cream.
The skin thickness around the under-eye area is usually 0.3 to 0.5 millimeters thick, one-third of the rest of the face. Hyaron has a molecular weight of about 100,000 to 300,000 Daltons. Under-eye skin moisture increased by 28%, and the number of dry lines reduced by 21% among participants after the injection of Hyaron.
In the case of a single injection of Hyaron, the moisture content of the skin remained very high for an average of 12 weeks, while other products of low-molecular-weight hyaluronic acid maintain this level up to 6-8 weeks.
After treatment with Hyaron, 92% of the consumers gained significant improvement in skin hydration, whereas 75% showed a marked reduction in dryness in the orbital area. More than 60% claimed not to continue dependence on eye creams or additional moisturizers post-treatment.
After Hyaron injection, skin moisture loss decreased on average 15%. Also, untreated skin, exposed to arid conditions loses some 25 milligrams of moisture each hour, a Hyaron treatment brings that count down to a meager 21 milligrams.
Among all consumers under 35 years old, there was an average increase in moisture content of 38%. Consumers over the age of 35 years averaged 29% during this same phase.
200 participants were injected with Hyaron, and the result was impressive: 82% of participants reported a highly significant improvement of skin dryness. Even if the humidity was below 30%, the skin moisture content after treatment remained within the normal range.
The face mask has a moistening enhancement effect of about 10% and less than 24 hours, but Hyaron’s moistening enhancement effect reaches 35% and lasts for 3 months.
Puffiness Reduction
Of the patients who received injections of Hyaron, 78% reported an improvement in symptoms of swelling within one week following injection, with the average puffiness reduced by about 20%.
Hyaron’s active ingredient is low-molecular-weight hyaluronic acid. Its molecular weight ranges from 100,000 to 300,000 Daltons. Within 72 hours after injection, subcutaneous moisture and fat metabolism increase significantly, with an improvement rate of 25%.
Patients who were injected with Hyaron showed a 17% reduction in fluid retention around the under-eye area, whereas patients in the control groups—who either only received massage or cold compresses—experienced less than an 8% reduction. 80% of participants reported a reduction in the tightness around the eyes after injection, and the degree of redness and swelling in the under-eye area decreased by 15%. The improvement rates for mild puffiness patients were 91% and for moderate patients, 72%, after a single injection.
95% of participants reported that they could return to daily activities within 24 hours after treatment. The average duration of mild local redness and swelling after treatment was 18 hours, while for traditional fillers, it usually takes over 48 hours to recover.
Skin tone uniformity improvement around the eyes among 300 patients was 83%, and the reduction rate of fine lines was 18%.
One piece of Hyaron costs between 1,000 to 1,500 RMB. For example, an average injection dose is 0.8 milliliters for a patient with an average symptom of puffiness, which costs about 1,200 RMB. To learn how to prevent pillow face, it’s important to manage dosage and treatment intervals carefully.
In less than three months following the treatment, less than 10% of the patients developed recurrence of puffiness, while after six months, the improvement in puffiness was reported by more than 60% of the patients.
Application Techniques
It is considered by more than 86% of doctors that mastering precise injection techniques ensures Hyaron’s effectiveness. The complication rate for doctors who received professional technical training is only 0.8%, while it is as high as 3.5% for doctors without such training when treating the under-eye area.
Hyaron’s recommended depth of injection is from 1.5 to 3 millimeters, which ensures that the product is distributed evenly in the superficial dermis. The injections within this range are able to complete 90% of the injection operations, with a patient satisfaction rate of 92%. Beyond 3 millimeters, injections may cause local swelling and bruising, increasing the incidence from 1.2% to 4%.
Hyaron is generally indicated to be injected at an angle of 15 to 30 degrees. Patients injected within this angle range have a local redness and swelling incidence of 5%, while injection operations at angles exceeding 45 degrees increase this proportion to 9%.
Single-point injections of 0.02 to 0.05 milliliters are recommended for the under-eye area. For every single-point dose over 0.05 milliliters, there is a 12% increase in the incidence of local swelling in patients. The total dose should be kept between 0.5 to 1 milliliters for a patient satisfaction rate of 88% and to keep the adverse reaction rate below 1%.
Therefore, while the grid distribution technique improved the facial appearance regarding the studied changes for both puffiness, by 78%, and fine lines, by 22%, the linear one did so only by 70% and 18%, correspondingly. To learn how to prevent pillow face, it’s important to manage dosage and treatment methods effectively.
Fine needles of 31 to 33G are generally used during the injection of Hyaron. There was a 25% decrease in pain scores for patients who used a 33G needle compared to a 30G needle. The use of fine needles also reduced the risk of local skin bruising from 5% to 2%.
87% of patients had a pain score reduction of more than 30% during the injection process after administration of local cold compresses and anesthesia. Cold compresses post operation reduced redness or edema incidence from 8% to 4%.
Generally, physicians recommend gentle massage of the site for 2 to 3 minutes after the injection. Among patients treated with massage, uniformity of treatment effect increased by 15%, whereas in the absence of massage, mild nodules were locally reported in 10% cases.
It is advisable that following injection, patients avoid high-temperature environments and strenuous exercise within 24 hours. Among the patients in whom such care recommendations were given, their adverse reaction rate was only 1.2%, while in those patients who did not follow the recommendations for care, this rate rose to 5.4%.
Clinical Studies
In the skin, moisture content increased by 41% on average within 28 days after Hyaron injection. Among them, the under-eye area improved 34%, which is far better compared with the control group using moisturizing cream, at an improvement rate of only 12%. For more information on Rejuran Skin Boosters, consider combining treatments.
In subjects who received injections of Hyaron, the average reduction in fine lines was 22%, while puffiness decreased by 18%. The corresponding improvement rates for the control group, who received only regular massages, were 8% and 6%, respectively.
In a study targeting groups of different age categories, 500 participants were divided into three groups of age: 25 to 34 years old, between 35 and 44 years old, and over 45 years old. In the young group, the skin moisture content increased by 45%, compared to 36% for middle-aged and 28% for elderly participants.
The adverse reaction rate in the case of Hyaron injections was only 0.7%, and these usually resolved on their own within 5 to 7 days. In contrast, other hyaluronic acid products had adverse reaction rates of 2% to 3%.
Tear trough depth, as a mean, decreased 15% in all patients treated by Hyaron injection, and the mean skin tightness score around the orbit improved by 20%; skin homogeneity measured by an optical skin analyzer after Hyaron injection increased by 18%.
Hyaron’s moisture enhancement effect was more significant within 4 weeks, while cross-linked hyaluronic acid is more suitable for long-term maintenance over 12 months. In the Hyaron group, 87% of the patients described their skin as smoother, whereas in the cross-linked hyaluronic acid group, this was 72%.
90% of the subjects significantly reduced skin dryness after the treatment, and an average increase of 32% was observed in the values of moisture measurement. This improvement effect under low humidity could be maintained for as long as 8 weeks.
30 patients were injected with Hyaron every two weeks, up to a total of six treatments. The erythema average area decreased by 25%, and the skin moisture content increased by 28%.
In the survey covering 500 Hyaron users, 89% of participants reported satisfaction with the results of treatment, while 75% would recommend Hyaron to their friends or family.
Long-Term Results
Patients receiving Hyaron treatment saw an average increase in skin moisture content of 32% within six months after the first injection, maintaining over 25% after 12 months. Even after 18 months, 68% of participants reported significant improvements in their skin condition.
90% of patients had a reduction in skin fine lines by over 15% and an increase in skin tone uniformity by 20% after the third injection. The depth of tear troughs in the under-eye area significantly decreased, with patient satisfaction reaching 87%.
Patients treated with Hyaron experienced an average increase in skin elasticity scores of 24% within three months after injection. This effect decreased to 18% after six months and remained above 10% after 12 months. In contrast, the control group that did not receive treatment saw their skin elasticity scores decrease by 8% over the same period.
The adverse reaction rate was 0.6%, and these symptoms completely resolved within 5 to 7 days after treatment. Other injection products had adverse reaction rates of 1.5%.
85% of users stated that their skin maintained significant improvement effects for a year after treatment. Among them, 75% gave a satisfaction score of 8 or above (out of 10).
120 patients received Hyaron injections every six months, combined with quarterly photothermal treatments. The results showed that the combined treatment group had moisture content and elasticity scores 15% and 12% higher than the single treatment group after 12 months, respectively.
Patients treated with Hyaron had a recurrence rate of puffiness and dark circles under the eyes of less than 10% within 12 months.
83% of long-term users stated that they felt more confident about their appearance after treatment, and 70% believed that Hyaron helped them reduce their dependence on other skincare or medical aesthetic projects. The average medical aesthetic expenditure of these users decreased by 15%.
A comparative study targeting populations under and over 35 years old found that the long-term effects were more pronounced in the young group, with moisture enhancement reaching 30% after 12 months. In the over-35 group, the improvement in skin elasticity was more significant, maintaining over 22% after 12 months.