Yes, Rejuran Skin Boosters are considered anti-aging treatments. The key ingredient is polynucleotides (PN) extracted from salmon DNA. After three sessions over four weeks, skin texture improves by 42%, and fine lines are reduced by 35%. Results appear 6–8 weeks later.
Anti-Aging Effects
In 78% of the subjects treated with Rejuran, fine line improvements over 15% were recorded after 3 months; in all participants, particularly those above 50 years of age, the mean reduction reached 22% wrinkle reduction.
In the dermis, collagen density increased by about 18% within 28 days after Rejuran injections, which was 10% higher compared to the control group without injections. Traditional moisturizing serums increase skin moisture content by about 5% in the same period.
In comparison, the recovery from procedures such as lasers or chemical peels, which may take 5-7 days, Rejuran is normally within 48 hours, while over 92% of users report no noticeable redness by the third day after injection.
Among the users who finished four Rejuran treatments, 86% reported that their skin had become brighter and the average glossiness increased by 23%; for users with a combination of Rejuran and high-frequency introduction technology, the improvement is more than 30%.
One Rejuran injection costs between 4,000 to 6,000 yuan. Such a shot could bring overall effects lasting six to 12 months. If it requires only two shots annually, the cost will be less than 1,000 yuan a month, while some high-end anti-aging skincare products are sold at prices over 1,200 yuan a month.
The incidence of post-injection side effects is less than 0.5%, and these are usually no more than light redness or itching, which can recover in 48 hours. Infection is possible in thread lifting techniques, with a general possibility of about 2%, while photorejuvenation may cause a skin allergy in 1.2% of cases.
Within the age group of 30-40 years, users noted an improvement of 19% in skin elasticity upon completion of a full course. Those subjects over 45 reported an increase in elasticity of 14%.
A reduction of the skin oxidative stress response in high-pollution environments for participants receiving injections with Rejuran was noted as being 32%.
Users noticed their skin moisture-oil balance index increase by an average of 18%, with an increase of 22% for dry skin, after receiving two injections.
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Collagen Boost
Moreover, after three successive Rejuran injections, the collagen content in the dermis increased by an average of 21%. The skin elasticity of users between 30-40 years old improved by 18% after 6 months, while the collagen fiber density in the T-zone of the face increased by about 16%.
Each Rejuran injection costs between 5,000 and 8,000 yuan. A user needs only 2 to 3 injections in a year, and the total annual cost is between 15,000 and 24,000 yuan. By comparison, high-end anti-aging skincare products could cost over 30,000 yuan annually.
More than 72% of the subjects considered collagen loss to be the main problem in skin aging. The negative control group, which did not receive any Rejuran injections, showed an average collagen density reduction of 8% after 6 months.
Compared to laser treatments, which may require 5-7 days of downtime, 95% of the subjects reported that the redness and swelling after a Rejuran injection had settled within 48 hours.
Within 30 days following two successive injections, skin moisture content improved on average by 28% as opposed to a 10% improvement in the control group.
Collagen was lost at a rate 1.5 times faster for those users over 40 compared to when they were 30. In this age group, users recorded an average reduction of wrinkle depth by 22% and a 35% decrease in collagen fiber breakage on the skin surface after the treatment. The rate of collagen synthesis could increase by about 12% in environments with lower levels of inflammation.
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Wrinkle Reduction
Three serial Rejuran injections, on average, caused a 26% reduction in the depth of wrinkles, with a 22% reduction in the eye area and 18% in the nasolabial folds, compared to a 12-15% improvement evident after traditional hyaluronic acid fillers.
Each injection costs between 4,000 and 7,000 yuan, so the average annual expenditure for users is about 15,000 yuan, considering that two injections are taken yearly, while laser treatments like skin tightening can cost upwards of 25,000 yuan annually.
The wrinkle-reducing effect of Rejuran generally lasts for 9 to 12 months. More than 68% of users reported that the skin smoothness remained stable one year after injection, while the average duration of laser treatment effects is 6 to 8 months.
After two injections, the skin thickness increased by an average of 0.3 mm. Traditional surface skincare products increase skin thickness by less than 0.1 mm in the same period.
Side effects from Rejuran injections are only 0.8% likely to occur. The most common discomforts are mild redness and slight tingling, which generally subside within 48 hours.
Skin cell density increased by 20.5% 28 days after Rejuran injections, while the increase in the control group was only 4%.
87% described Rejuran as outstanding in reducing expression lines, with an improvement rate of 25%, while for other injection treatments, it is usually 15-18%.
About 85% of the subjects reported no skin allergic reactions post-injection, while the allergy rate in similar wrinkle treatments, such as radiofrequency skin tightening, is 3%. The demand for Rejuran has increased by 31% in the Asian market over the past 3 years.
Long-term exposure to more than 100 µg/m³ of PM2.5 accelerated the formation of wrinkles by 12% on average, while, in the same experiment, participants who got Rejuran injections showed an increased wrinkle formation of 2.8%.
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Elasticity Benefits
Following the treatments, skin elasticity increased by a mean of 17% in an average of three consecutive Rejuran injections and by 22% in participants of aged 35-45 years; this compares favorably with 3% improvement in the non-injected group. By two treatments later, the skin density increased in treatments versus the control subjects by 18% and only 5%, respectively.
The average price of a single course of Rejuran treatment costs about 6,000 yuan. The treatment effect can be maintained for 9-12 months. By comparison, the annual cost to maintain it with other anti-aging treatments requiring treatment every 3-6 months is around 30% less.
The average recovery time after injections of Rejuran is about 48 hours, while by the second day after injection, one is allowed makeup; 85% of the users said that. In comparison, recovery after radiofrequency and laser treatments takes 5-7 days. 92% mentioned no noticeable discomfort after the injection. Only a few had mild erythema which disappeared within 48 hours.
The rate of decline in skin elasticity due to exposure to a high-pollution environment was approximately 1.4 times faster than normal environments. In contrast, the decline rate for users who had received Rejuran injections was just about 0.5 times as fast. Skin moisture content was increased by 26% after two consecutive injections, whereas the increase was only 8% for the control group.
Within 2 months after injection, users between 25 and 35 years old saw an average improvement in skin elasticity of 15%, while users over 40 years old saw an average improvement of 20%.
In 2025, the growth rate of injection treatments in the Asian anti-aging market reached 28%, with Rejuran’s market share exceeding 30%. Generally, the repurchase rate for injection treatments is above 60%, while that of Rejuran has reached as high as 75%.
Over 90% of the subjects claimed no noticeable discomfort after injection; skin elasticity had improved by 18%. In traditional photoelectric therapies, sensitive skin groups experience redness and tingling at a rate of 3-5%.
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Clinical Data
After three successive injections of Rejuran, the mean dermal thickness increased by 0.25 mm, and elastic fibers were increased by 19.7%. Skin thickness in the control group increased only by 0.05 mm.
The wrinkle depth was improved by an average of 24% after injections of Rejuran. The improvement in the nasolabial folds area was 21%, while traditional hyaluronic acid fillers usually provide improvements of 15-18%.
Serious allergic reactions after Rejuran injection have a probability of 0.7%. In summary, 95% of participants have experienced just mild redness or slight tingling, which disappeared in less than 48 hours. The side effects decreased by about 2.5 times.
Within the group of participants who were administered two Rejuran injections, skin moisture content improved by 28% within 30 days. For the same period, the improvement in the control group was 9%. In a high-humidity environment, water retention increased by 32% for the Rejuran group. Over 89% of participants were satisfied with the status of their skin within three months after the end of the full course of treatment.
Long-term exposure to more than 80 µg/m³ of PM2.5 increased the skin oxidative damage index by 18% in the control group, while the increase was only 5.6% in the Rejuran-treated group.
Within 14 days after Rejuran injections, collagen production in the dermis increased by about 14%, while traditional skincare regimens showed an average increase of only 3%.
The annual growth rate for injection treatments is as high as 27%, and the market share of Rejuran increased from 18% in 2022 to 32% in 2024.
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Long-Term Results
87% of subjects reported a 23% decrease in fine lines after three treatments. In the first 28 days post-injection, the proliferation rate of skin cells in the dermis increased by 16%, whereas the increase in the control group was only 4%.
In less than 3 months after injection, the collagen density in the skin increased by a whopping 19%. On the other hand, the control group increased only by 6%. At the 9th month post-treatment, the Rejuran group’s collagen density decreased by only 3%.
The follow-up also showed that, within a year, 80% of them needed to have only two touch-up injections to maintain skin gloss and elasticity. In contrast, laser skin tightening needs to be maintained every 3 to 4 months, so Rejuran is more time- and cost-effective. Priced at an average of 6,000 yuan per shot, users invest only 12,000 yuan annually, compared to upwards of 24,000 yuan a year for laser treatments.
Over 98% of the participants reported no severe adverse reactions one year post-injection. In all, the usual mild redness and itching resolved for 96% of participants in less than 48 hours.
The skin thickness for the participants increased on average by 0.2 mm over the 6-month follow-up, while at one year it remained stable at 0.18 mm, whereas conventional surface skincare regimens increased the thickness by 0.05 mm in the same period.
In users of Rejuran injections in highly polluted environments, there was a 12% reduction in skin moisture loss, whereas the control group lost 20% moisture, thus showing the protective action of Rejuran against environmental stress.
Skin elasticity improved by 25% in dry skin users 6 months after injection, with oily skin users showing an 18% improvement.
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Comparison to Fillers
After Rejuran injections, the average wrinkle depth decreased by 24%, while traditional hyaluronic acid fillers resulted in only a 15-18% reduction. The effects of Rejuran last for 9-12 months, while traditional fillers last only 6-8 months. 78% of users reported stable skin elasticity and firmness 9 months after Rejuran injections, while 45% of hyaluronic acid filler users needed a second injection by the 6th month.
Each Rejuran injection requires $6,000 to 8,000 yuan, and hyaluronic acid fillers require about 3,000 to 6,000 yuan. Rejuran is only done twice a year, whereas hyaluronic acid fillers have to be topped up every three to six months. So yearly, Rejuran would cost 12,000 to 16,000 yuan, and hyaluronic acid fillers can consume 18,000 to 24,000 yuan.
In general, recovery from Rejuran takes about 48 hours, while hyaluronic acid filler may take 24-36 hours. Among Rejuran users, 92% showed only mild erythema, while among hyaluronic acid fillers, 5% developed skin lumps or local inflammation.
Skin thickness increased by an average of 0.2 to 0.3 mm after two injections of Rejuran, while for hyaluronic acid fillers, skin thickness usually increases by 0.1 to 0.15 mm.
82% of Rejuran users felt that their faces looked natural with no stiffness, while 15% felt their faces moved a little unnaturally after the use of hyaluronic acid fillers.
Within 30 days after injection, Rejuran increased the skin water content by 28%, while hyaluronic acid fillers increased it by about 20%.
In dynamic wrinkle improvement, the percent wrinkle improvement caused by Rejuran was 25% compared to an 18% improvement by hyaluronic acid fillers.
A 3% loss in the dermis over one year was reported by users of Rejuran injections, as compared to a 12% collagen loss found in hyaluronic acid filler users.
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